Photolabile μ-conotoxins with a chromogenic phenyldiazirine
نویسندگان
چکیده
منابع مشابه
μ-Conotoxins Modulating Sodium Currents in Pain
The Conus genus includes around 500 species of marine mollusks with a peculiar 9 production of venomous peptides known as conotoxins (CTX). Each species is able to produce up 10 to 200 different biological active peptides. Common structure of CTX is the low number of 11 aminoacids stabilized by disulfide bridges and post-translational modifications that give rise to 12 different isoforms. μ and...
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Neurotoxin receptor site 1, in the outer vestibule of the conducting pore of voltage-gated sodium channels (VGSCs), was first functionally defined by its ability to bind the guanidinium-containing agents, tetrodotoxin (TTX) and saxitoxin (STX). Subsequent studies showed that peptide micro-conotoxins competed for binding at site 1. All of these natural inhibitors block single sodium channels in ...
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The cross section of ee → bb̄ud̄μ−ν̄μ process with a complete set of tree diagrams, 232 diagrams in the unitary gauge, was calculated at the energy range of √ s = 340 500 GeV by using GRACE system. A main contribution to the cross section comes from tt̄ production, where t and t̄ decay into bud̄ and b̄μ−ν̄μ, respectively. It was found that the interference between the diagrams with tt̄ production and th...
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Conotoxins are small peptides present in the venom of cone snails. The snail uses this venom to paralyze and capture prey. The constituent conopeptides display a high level of chemical diversity and are of particular interest for scientists as tools employed in neurological studies and for drug development, because they target with exquisite specificity membrane receptors, transporters, and var...
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The pharmacological variety of conotoxins, diverse peptides found in the venoms of marine cone snails, is well recognized. Venoms from each of the estimated 500 species of cone snails contain 50 to 200 distinct biologically active peptides. Most conotoxins characterized to date target receptors and ion channels of excitable tissues, such as ligandgated nicotinic acetylcholine, N-methyl-D-aspart...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1990
ISSN: 0014-5793
DOI: 10.1016/0014-5793(90)80057-p